Validation of human papillomavirus genotyping by signature DNA sequence analysis
نویسندگان
چکیده
منابع مشابه
Validation of human papillomavirus genotyping by signature DNA sequence analysis
BACKGROUND Screening with combined cytologic and HPV testing has led to the highest number of excessive colposcopic referrals due to high false positive rates of the current HPV testing in the USA. How best to capitalize on the enhanced sensitivity of HPV DNA testing while minimizing false-positive results from its lower specificity is an important task for the clinical pathologists. METHODS ...
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Background & Aims: Around the world, cervical cancer is the second most common cancer in women. Today, screening programs have reduced morbidity and mortality rates of this disease. Epidemiological and molecular studies have shown that certain types of the human papillomavirus are carcinogen types and the primary cause of cervical cancer. HPV type 16 and 18 are the most common high-risk types. ...
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AIMS Persistent infection indicated by detection of human papillomavirus 16 (HPV-16) on repeat testing over a period of time poses the greatest cervical cancer risk. However, variants of HPV-16, HPV-31 and HPV-33 may share several short sequence homologies in the hypervariable L1 gene commonly targeted for HPV genotyping. The purpose of this study was to introduce a robust laboratory procedure ...
متن کاملClinical significance of human papillomavirus genotyping.
Cervical cancer is the fourth most common cancer in women worldwide, and the human papillomavirus (HPV) is the main causative agent for its development. HPV is a heterogeneous virus, and a persistent infection with a high-risk HPV contributes to the development of cancer. In recent decades, great advances have been made in understanding the molecular biology of HPV, and HPV's significance in ce...
متن کاملCervical Cancer and Genital Infections: Assessment of Performance and Validation in Human Papillomavirus Genotyping Assays in Iran, its Neighbouring Countries and Persian Gulf Area
Background: The accuracy of diagnostic assays in Human Papillomavirus (HPV) genital infection and cervical cancer has remained a clinical challenge in diagnosis. Evidence indicates that a large proportion of cervical cancer can be prevented through organized care for HPV and testing. Countries with low per capita income, such as Iran and its neighbour...
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ژورنال
عنوان ژورنال: BMC Clinical Pathology
سال: 2009
ISSN: 1472-6890
DOI: 10.1186/1472-6890-9-3